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  1. General Info
  2. Effects Info
  3. Reference
Drug Interaction Details
01. General Information
Pair Name Mangiferin, Cisplatin
Phytochemical Name Mangiferin (PubChem CID: 5281647 )
Anticancer drug Name Cisplatin (PubChem CID: 5702198 )
Structure of
Phytochemical		 2D-img
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2D MOL 3D MOL
Structure of
Anticancer Drug		 2D-img
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2D MOL 3D MOL
02. Combinatorial Therapeutic Effect(s)
Synergistic Effect
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Decreasing Drug Toxicity
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The theory of cold and heat
Drug Name Cisplatin
Adverse Reactions Myelosuppression, dry mouth and throat, fever, dry stools. This was inferred hot nature anticancer drug.
Recommendations Cold: Anemarrhena asphodeloides; Urena lobataL; Artemisia scoparia; Swertia mussotii; Swertia pseudochinensis; Gentiana manshurica; Gossampinus malabarica; Pyrrosia sheareri; Pyrrosia sheareri; Iris domestica; Gentiana scabra; Pyrrosia sheareri; Pyrrosia petiolosa
Reference ADReCS-Target: target profiles for aiding drug safety research and application. Nucleic Acids Res. 2018 Jan 4;46(D1):D911-D917. doi: 10.1093/nar/gkx899.　　ref_link
Combination Pair ID: 453
Ref_1
Pair Name Mangiferin, Cisplatin
Disease Info Nephrotoxicity Investigative
Biological Phenomena Induction-->Apoptosis
Gene Regulation Up-regulation Expression BAX hsa581
Down-regulation Expression BCL2 hsa596
Down-regulation Expression CAPN1 hsa823
Down-regulation Cleavage CASP12 hsa100506742
Down-regulation Cleavage CASP3 hsa836
Up-regulation Expression HMOX1 hsa3162
Down-regulation Expression MYC hsa4609
Up-regulation Expression NFE2L2 hsa4780
Up-regulation Expression PIK3CA hsa5290
Up-regulation Expression SOD2 hsa6648
In Vitro Model MCF-7 Invasive breast carcinoma of no special type Homo sapiens (Human) CVCL_0031
SK-RC-45 Clear cell renal cell carcinoma Homo sapiens (Human) CVCL_4016
EAC-E2G8 Malignant neoplasms of the mouse mammary gland Mus musculus (Mouse) CVCL_WJ08
In Vivo Model Four weeks old male swiss albino mice were used for this study.
Result The study reveals a mechanistic basis of mangiferin action against cisplatin induced nephrotoxicity. Since Mangiferin shows synergistic anticancer activity with cisplatin, it can be considered as a promising drug candidate, to be used in combination with cisplatin.
03. Reference
No. Title Href
1 Mangiferin Ameliorates Cisplatin Induced Acute Kidney Injury by Upregulating Nrf-2 via the Activation of PI3K and Exhibits Synergistic Anticancer Activity With Cisplatin. Front Pharmacol. 2018 Jun 18;9:638. doi: 10.3389/fphar.2018.00638. Click
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